DNA-based bird flu vaccine promising
A DNA-based vaccine against bird flu can safely
stimulate the immune system to levels expected to protect against flu, reports
According to the company, in a study of 100 volunteers, 67% of the patients
receiving the higher dose had immune responses that could protect against H5N1
infection, with no serious adverse reactions after two injections.
"The preliminary results from this Phase 1 trial indicate for the first
time that ... DNA vaccination against H5N1 influenza is well-tolerated and can
induce impressive antibody responses," said Dr Robert Belshe of Saint Louis
University School of Medicine.
Vical said that this DNA-based vaccine could be made in 6-8, by making use
of genetic material called plasmids, which are meant to generate an immune
response against a specific bit of the virus.
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